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The Browns will be without one of their key pieces on offense for the immediate future.
Jerome Ford was injured during the team's comeback win over the Colts in Indianapolis on Sunday.
The running back suffered a "low-grade, high ankle sprain" and ESPN reports he'll be sidelined for "one-to-two" weeks.
Cleveland is 4-and-2 on the season heading into a Sunday afternoon showdown against the Seahawks in Seattle.