Jose Ramirez had three hits and two RBI to help the Indians beat the Twins 6-2 in Minnesota.
Francisco Lindor contributed two singles and scored twice in the win.
Trevor Bauer pitched into the seventh inning for his 10th win.
Cody Allen got the final four outs for his 21st save.
The Indians and Twins play the rubber match of their three-game series at Target Field this afternoon.
Cleveland is 58-and-48, nine games ahead of Minnesota for first in the AL Central.
Carlos Carrasco heads to the bump for the Indians.
The Twins counter with Adalberto Mejia.