Robbie Grossman plated two on a single in the seventh to lift the Twins to a 4-3 win over the Indians at Progressive Field.
Cody Allen was tagged with the loss.
Three different players had a RBI for the Indians, who have split the first two in the three-game series.
The Indians and Twins play the rubber match of their three-game set this afternoon at Progressive Field.
Cleveland is 75-and-57, 13 games ahead of Minnesota for first in the AL Central.
Mike Clevinger heads to the bump for the Indians.
Minny counters with Jake Odorizzi.