Ryan O'Hearn went 3-for-4 with a double and two home runs to help power the Royals to a 5-1 win over the Indians in Cleveland.
Adam Plutko took the loss for the Tribe.
Francisco Lindor homered in the ninth to break up the shutout for Cleveland.
The Indians have lost three in-a-row.
The Indians continue their series with the Royals tonight at Progressive Field.
Mike Clevinger will take the ball for the Tribe in the opener.
Kansas City will counter with Danny Duffy.
The Indians still hold a 14-game lead over Minnesota atop the AL Central.