Francisco Lindor had four hits, including two home runs, and drove in four to help the Indians beat the Blues Jays 9-4 in Toronto.
Jason Kipnis chipped in with a three-run blast for the Tribe.
Shane Bieber pitched into the seventh inning to earn the win in the opener of the four-game series.
The Indians play the second of four games against the Blue Jays in Toronto tonight.
Cleveland is 80-and-60, 16-and-a-half games ahead of the Twins for first in the AL Central.
Carlos Carrasco takes the mound for the Indians opposite the Blue Jays' Marco Estrada.