The Cavaliers blew a double-digit, first-half lead and lost to the Nuggets 110-91 in Cleveland.
Jordan Clarkson came off the bench to lead the Cavs with 17 points in just 19 minutes of floor time.
Cedi Osman added 13 points in defeat.
The Cavaliers played again without Kevin Love, who is out for an extended time with a foot injury.
Cleveland will go back on the road for the next two games.
The Cavs face the Hornets in Charlotte tomorrow and the Magic Monday in Orlando.